Kristen Stewart is actually up against herself -- for her passionate smooch with Robert Pattinson in "New Moon," vs. her girl-on-girl lip-lock with Dakota Fanning in "The Runaways."
"Twilight" co-star Taylor Lautner also gets a nod for his kissing skills with former girlfriend Taylor Swift in another flick, "Valentine's Day."
Rounding out the Best Kiss category are Sandra Bullock and Ryan Reynolds in "The Proposal" and Zoe Saldana and Sam Worthington in "Avatar."
Voting starts at 12 p.m. ET Wednesday at MovieAwards.MTV.com. Tune in to see who puckers up best on June 6 on MTV, when host Aziz Ansari takes the stage to present the lucky winners during the live show.